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JWH-210 ; (4-ethylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone · Synthetic cannabinoids · Synthetic cannabinoid receptor agonists · 824959-81-1.

• JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with K_i values of 0.46 nM at CB₁ and 0.69 nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB₁ K_i 0.69 nM) and JWH-182 (CB₁ K_i 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB₁ K_i 1.2 nM).^[2] It was discovered by and named after John W. Huffman.